李伟

李伟，男，博士，教授，硕士研究生导师。

1992.09-1996.07四川师范学院化学系化学教育专业学习获学士学位

1999.09-2002.07重庆大学化学化工学院物理化学专业学习获硕士学位（导师：刘信安教授）

2006.09-2009.07重庆医科大学药学院药理学专业学习获博士学位（导师：余瑜教授）

1996.09-1999.07四川省阆中市老观中校高中化学教师

2002.07-至今 重庆医科大学药学院工作，先后担任药物化学、药剂学和有机化学教研室副主任、主任，现任重庆医科大学药学实验中心副主任。

承担本科生《有机化学》、《医用化学》和《医学化学实验》等课程的教学工作。主持中华医学会、重庆医科大学教学研究重点和一般项目共3项，获中华医学会医学化学学会优秀教学成果奖；发表教学研究论文8篇；副主编或参编《有机化学》、《医用化学》、《医学化学实验》等教材共计14部。

研究方向：

生物催化不对称合成及手性药物新工艺、新型药物递送系统研究。

近年发表的代表性论文：

[1]Shan Shi, Meiting Cao, Yang Li, Liping Zhou, Shurong Zhang, Xiaoyue Wang, Juan Xin andWei Li*.Sequential targeting dual-responsive magnetic nanoparticle for improved therapy of lung metastatic breast cancer.J. Drug Target.,2023,31, 655-669.(独立通讯作者)

[2]Xin Wang, Yijian Zhu, Xudong Zhao, Shurong Zhang, Meiting Cao, Xiaoyue Wang andWei Li*. Development and characterization of an amorphous curcumin-Eudragit@E100 solid dispersions with improved solubility, stability, and pharmacokinetic properties.Pharm.Dev. Technol.,2022, 27, 965-974.(独立通讯作者)

[3]Yan g Li, Shan Shi, Shurong Zhang, Zongjie Gan, Xin Wang, Xudong Zhao, Yijian Zhu, Meiting Cao, Xiaoyue Wang andWei Li*. ctc-[Pt(NH₃)₂(cinnamate)(valproate)Cl₂] is a highly potent and low-toxic triple action anticancer prodrug.Dalton Trans.,2021, 50, 11180-11188.(独立通讯作者)

[4]Yutong Dai, Qingman Li, Shurong Zhang, Shan Shi, Yang Li, Xudong Zhao, Liping Zhou, Xin Wang, Yijian Zhu,Wei Li*. Smart GSH/pH dual-bioresponsive degradable nanosponges based on β-CD-appended hyper-cross-linked polymer for triggered intracellular anticancer drug delivery.J. Drug Deliv. Sci. Tec.,2021, 64,102650.(独立通讯作者)

[5]Li Zhou,Wei Li, Yilin Wen, Xiaoxue Fu, Feng Leng, Jiaxin Yang, Lu Chen, Xiaojuan Yu, Chao Yu, Zhangyou Yang. Chem-inspired hollow ceria nanozymes with lysosome-targeting for tumor synergistic phototherapy.J. Mater. Chem. B,2021, 9, 2515- 2523.(共同第一作者)

[6]Jing Li, Qian Chen, Shurong Zhang, Qihua Jiang, Jingchuan Shang, Liping Zhou, Qiang Li, Shanshan Li, Shan Shi, Yang Li,Wei Li*. Maltosyl-β-cyclodextrin mediated Supramolecular Host-Guest inclusion complex used for enhancing baicalin antioxidant activity and bioavailability.J. Drug Deliv. Sci. Tec.,2019, 54, 101346. (独立通讯作者)

[7]Qian Chen, Baogang Xie, Liping Zhou, Lili Sun, Shanshan Li, Yuhan Chen, Shan Shi, Yang Li, Mingan Yu,Wei Li*. A Tailor-Made Self-Sufficient Whole-Cell Biocatalyst Enables Scalable Enantioselective Synthesis of (R)?3-Quinuclidinol in a High Space-Time Yield.Org.Process Res.Dev.,2019, 23,1813-821.(独立通讯作者)

[8]Shiwei Wang, Yi Hou, Shurong Zhang, Jing Li, Qian Chen, Mingan Yu,Wei Li*. Sustained antibacterial activity of berberine hydrochloride loaded supramolecular organoclay networks with hydrogen-bonding junctions.J. Mater. Chem. B,2018, 6, 4972-4984.(独立通讯作者)

[9]Yuhan Chen, Qihua Jiang, Lili Sun, Qiang Li, Liping Zhou, Qian Chen, Shanshan Li, Mingan Yu,Wei Li*. Magnetic Combined Cross-Linked Enzyme Aggregates of Ketoreductase and Alcohol Dehydrogenase: An Efficient and Stable Biocatalyst for Asymmetric Synthesis of (R)-3-Quinuclidinol with Regeneration of Coenzymes in Situ.Catalysts,2018, 8, 334.(独立通讯作者)

[10]Mingan Yu, Duqiang Liu, Lili Sun, Jing Li, Qian Chen, Lijun Pan, Jingchuan Shang, Shurong Zhang,Wei Li*. Facile fabrication of 3D porous hybrid sphere by co-immobilization of multi-enzyme directly from cell lysates as an efficient and recyclable biocatalyst for asymmetric reduction with coenzyme regeneration in situ.Int. J. Biol. Macromol.,2017, 103, 424-434.(独立通讯作者)

[11]Jing Li, Qihua Jiang, Ping Deng, Qian Chen, Mingan Yu, Jingchuan Shang,Wei Li*. The formation of a host-guest inclusion complex system between β-cyclodextrin and baicalin and its dissolution characteristics.J. Pharm. Pharmacol.,2017, 69, 663-674.(独立通讯作者)

[12]Mingan Yu, Lijun Pan, Lili Sun, Jing Li, Jingchuan Shang, Shurong Zhang, Duqiang Liu,Wei Li*. Supramolecular assemblies constructed from β-cyclodextrin-modified montmorillonite nanosheets as carriers for 5-fluorouracil.J. Mater. Chem. B,2015, 3, 9043-9052.(独立通讯作者)

[13]Wei Li, Lili Sun, Lijun Pan, Zuopin Lan, Tao Jiang, Xiaolan Yang, Jianchun Luo, Ronghua Li, Liqing Tan, Shurong Zhang, Mingan Yu, Dendrimer-like assemblies based on organoclays as multi-host system for sustained drug delivery.Eur. J. Pharm. Biopharm., 2014, 88, 706-717.(独立第一作者)

[14]Mingan Yu, Lili Sun,Wei Li*, Zuopin Lan, Bibo Li, Liqing Tan, Ming Li, Xueheng Yang. Investigation of structure and dissolution properties of a solid dispersion of lansoprazole in polyvinylpyrrolidone,J. Mol. Struct., 2011, 1005, 70-77.(独立通讯作者)

专利：

[1]李伟,陈倩,刘笃强,李晶,于明安。一种生物催化剂及其制备方法和应用，授权公告号：CN 106701699 B.

[2]李伟,李珊珊,陈倩,石山,李阳;王鑫。一种双功能酶生物催化剂及其制备方法和应用,授权公告号：CN 112143718 B.

[3]尚京川，李晶，李伟，陈倩。丙烯酸酯功能化的桥键介孔载体材料及其制备方法，授权公告号：CN 106822917 B.

[4]孙立力，刘笃强，李伟，陈倩，李晶。磁性联合交联酶聚集体生物催化剂及其制备方法和应用，授权公告号：CN107227301B.

[5]余瑜，赵领，李伟，钟小东，梁艳，张雪梅。注射用肺靶向载药前体脂质体及其使用方法，授权公告号：CN 101474155 B.

主持课题:

[1]重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0212，在研，负责人)

[2]重庆市教育委员会自然科学基金面上项目(KJ1400212，结题，负责人)

[3]重庆市科学技术委员会(cstc2014jcyjA0019，结题，负责人)

[4]重庆医科大学药学院(创建5L发酵规模制备(R)-3-奎宁醇新工艺，11万，结题，负责人)

[5]重庆市科瑞制药集团有限公司横向合作项目(工程菌催化还原3-奎宁酮制备(R)-3-奎宁醇，41万，结题，负责人).

[6]国家自然科学基金面上项目(30772595，结题，第一主研)

      E-mail：li_wei@cqmu.edu.cn