梁国娟

梁国娟，硕士，副教授，硕士生导师

联系方式：100886@cqmu.edu.cn

主要研究方向为：

1）手性技术与手性药物研究2）不对称合成及手性药物新工艺研究

教育与工作经历

1998-2002年西南师范大学，化学教育专业，学士。

2002-2005年厦门大学，有机化学专业，硕士。

2005-至今重庆医科大学药学院，工作。

科研项目

1.重庆市科委项目(cstc2016jcyjA0250)，主持，结题

2.重庆市教委科学技术项目(KJ1702014)，主持，在研

3.药学院青年师资培育项目(YXY2019XSGG5)，主持，结题

教学工作

主要承担本科生《有机化学》《药物合成》、研究生《高等有机》等课程的教学工作，参与重庆市教育教学改革项目一项，并以通讯作者发表教改论文一篇；参编教材一部。

代表性论文（近5年）：

1.Qian Pu^#, Mingming Huo^#,Guojuan Liang^#, Lijuan Bai, Genhui Chen, Hongjiao Li, Peng Xiang, Hui Zhou* and Jing Zhou*,“Divergent oxidative dearomatization coupling reactions to construct polycyclic cyclohexadienones”chem.commun.2022，58, 4348-4351

2.Yuchen Yang^#, Cheng Tang^#,Guojuan Liang^#, Ping Deng, Jing Zhou, Zinan Yang, Peng Chen, andHui Zhou*, “Cooperative Heterobimetallic Zinc/Alkaline Earth Metal Catalysis: A Zn/Sr Aminophenol Sulfonamide Complex for Catalytic Asymmetric Michael Addition of 3Acetoxy-2-oxindoles to βEster Enones”J. Org. Chem.2021,86, 7119-7130.

3.Jing Zhou, Lijuan Bai,Guojuan Liang, Qigui Xu, Liping Zhou andHui Zhou*, “Organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substitutedp-QMs with α-nitroketones”Org. Biomol. Chem.2020,18, 2641-2645.

4.MingmingHuo,JingZhou,LijuanBai, QiguiXu, ZhihongZhou, HuiZhou,GuojuanLiang*. High diastereoselective synthesis of spiro-barbituratechromans via domino oxa-Michael/1,6-additionreactions of ortho-hydroxyphenylsubstituted para-quinone methides with barbiturate-based olefins.Tetrahedron,2019,75, 130752.

5.Guanghui Chen^#,Guojuan Liang^#, Yiwu Wang, Ping Deng,Hui Zhou*, “A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins”Org. Biomol. Chem.2018,16, 3841-3850.

6.Feilong He, Guanghui Chen, Junxia Yang,Guojuan Liang, Ping Deng, Yan Xiong,Hui Zhou*, “Catalytic enantioselective Henry reaction ofα-ketoesters, 2-acylpyridines and 2-acylpyridineN-oxides”RSC Adv.2018,8, 9414-9422.

7.Jing Zhou,Guojuan Liang, Xiangnan Hu, Liping Zhou,Hui Zhou*, “Facile synthesis of 3-aryl 2,3-dihydrobenzofurans via novel domino1,6-addition/O-alkylation reactions of para-quinone methides”Tetrahedron,2018,74, 1492-1496.

8.Shixiong Zhang, Ping Deng, Jing Zhou, Mouxiong Liu,Guojuan Liang, Yan Xiong,Hui Zhou*, “A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale”Chem. Commun.2017,53, 12914-12917. (Highlighted bySynfacts,2018,14, 285)

9.Jing Zhou, Lijuan Bai,Guojuan Liang, Yongjie Chen, Zongjie Gan, Wu Wang, Hui Zhou and Yu Yu*. Organocatalytic asymmetric domino Michael/O-alkylation reaction for the construction of succinimide substitubstituted 3(2H)-furanones catalyzed by quinine.RSC Advances,2017,7, 39885-39888.

10.Wu Wang,Guojuan Liang, Yan Bai, Lijuan Bai, Hui Zhou, Yu Yu, andJing Zhou*. A facile base-promoted domino Michael/O-alkylation reaction for the construction of succinimide-substituted 3(2H)-furanones.Arkivoc2017, part iv, 236-248.