聂神有，重庆医科大学药学院，新靶标与化学干预教育部医药基础研究创新中心特聘教授，博士生导师，重庆市巴渝青年学者。2014年博士毕业于中国科学院上海有机化学研究所，师从糖化学家俞飚研究员。2015-2020年分别在美国普渡大学化学系和贝勒医学院药理学和生物化学系进行博士后研究。2020-2024年，重庆医科大学生命科学研究院教授，2024年6月起重庆医科大学药学院特聘教授。主持包括国家自然科学基金面上项目等4项，参与国家重点研发计划、科技部“脑科学与类脑研究”青年科学家项目等科研项目等6项，以第一/通讯作者在J Am Chem Soc, Sci Adv, Theranostics, J Med Chem等高水平杂志发表论文20余篇，Front. Chem. 审稿编辑，Emerging Microbes Infect. 和Archiv Der Pharmzie等杂志审稿人。申请国内和国际专利10余项，获授权国际专利2项，美国专利1项，中国发明专利1项。

联系方式：nieshenyou@cqmu.edu.cn

ORCID ID：https://orcid.org/0000-0002-7396-8114

主要研究方向：

1）药物化学生物学：基于靶标的抑制剂与降解剂的开发与作用机制研究；

2）有机化学：新颖有机合成方法学高效建构特色伪天然产物小分子化合物库。

代表性论文（*通讯作者，#共同第一作者）

[1] Jiawei Zhang#, Fang Lin#, Yijie Xiao, Si-Yu Cen, Bi-Wen Wan, Xuan Li, Yahui Zhao, Yi He, Hai-Xin Yuan*,Shenyou Nie*. Discovery and optimization of 1,2,4-triazole derivatives as novel ferroptosis inhibitors.Eur. J. Med. Chem.2025, 284, 117192

[2] Boyi Zhang#, Hui Bai#, Beibei Zhan#, * Kaihang Wei,Shenyou Nie*, Xiaheng Zhang*. Deacylative arylation and alkynylation of unstrained ketones.Sci. Adv.2024, 10, eado0225.

[3]Shenyou Nie#, Yuan Yao#, Fangrui Wu#, Xiaowei Wu, Jidong Zhao, Yuanda Hua, Jingyu Wu, Tong Huo, Yi-Lun Lin, Alexander R. Kneubehl, Megan B. Vogt, Josephine Ferreon, Rebecca Rico-Hesse, and Yongcheng Song*.Synthesis, Structure-Activity Relationships and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.J. Med. Chem.2021,64, 2777–2800.

[4] Lijie Lv#, Kunlin Song#, Yijie Xiao#, Jia Zheng, Wei Zhang, Linfeng Li, Yue Wei, Hao Chen, Yi He, Zufeng Guo*,Shenyou Nie*, Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway.Bioorg. Chem.2024, 151, 107648.

[5] Lijie Lv#, Jia Zheng#, Yijie Xiao, Dan Ni, Zhangshun Luo, Yunyun Gao, Yue Wei, Yi He*, andShenyou Nie*. [4+2] Cyclization or Lossen Rearrangement: Rhodium-Catalyzed Divergent Synthesis of Carboline Derivatives with Anticancer Activity.Org. Lett.2024, 26, 4212-4217.

[6] Bi-Wen Wan #, Wei Liu #, Yijie Xiao # , Lijie Lv, Xuan Li, Fang Lin, Yahui Zhao, Yi He, Shenyou Nie*, Xiaoyu Yang*, Hai-Xin Yuan*. Discovery of novel benzo[b][1,4]oxazine derivatives as ferroptosis inhibitors.Bioorg. Chem.2025, 156, 108201.

[7] Feiyu Gao#, Chenxin Yin#, Yi He#, * Shuang Zhao, Mengxiao Chen, Jia Zheng, Dan Ni, Houhua Yin, Xian Fu, Xiaoyong Zhang*,Shenyou Nie*. Visible-light mediated Ugi-type reaction for the synthesis of 3,3-disubstituted phthalides.Adv. Synth. Catal.2024, 366, 2728-2734.

[8] Shuang Zhao#, Mengxiao Chen#, Wenlu Zhou, Dan Ni, Zhenghua Li,Shenyou Nie*, Yi He*. Green synthesis for diverse bioactive benzo-fused spiroindolines through DBU-catalysed post-Ugi double cyclization.Chem. Commun.2024, 60, 5455-5458.

[9]Shuang Zhao#, Yi He#, *, Feiyu Gao#, Yue Wei, Jiawei Zhang, Mengxiao Chen, Yunyun Gao, Yuan Zhang, Jun-yan Liu, Zufeng Guo, Zhenghua Li*,Shenyou Nie*. Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization.Chem. Commun.2023, 59, 3099–3102.

[10]Shenyou Nie#, Fangrui Wu#, Jingyu Wu#, Xin Li#, Chao Zhou, Yuan Yao, and Yongcheng Song*. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP.Eur. J. Med. Chem.2022, 237, 114407.

[11]Fangrui Wu#,Shenyou Nie#, Yuan Yao#, Tong Huo#, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qiangxing Mo, Yongcheng Song*. Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth.Theranostics,2021,11, 8172-8184.

[12]Yuan Yao#, Tong Huo#, Yi-Lun Lin#,Shenyou Nie#,Fangrui Wu#, Yuanda Hua, Jingyu Wu, Alexander R. Kneubehl, Megan B. Vogt, Rebecca Rico-Hesse, Yongcheng Song*. Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.J. Am. Chem. Soc.2019,141, 6832-6836.