陈 昶

重庆市引进高层次人才、副研究员、副教授

邮箱：chenchang@cqmu.edu.cn

研究方向

（1）代谢性疾病药物药理学

（2）药物体内代谢和转运

教育背景

·2009.9–2013.12澳大利亚阿德莱德大学医学科学院药理学博士

·2008.9–2009.6 华中科技大学同济医学院药学院 药理学 博士生

·2006.9–2008.6 华中科技大学同济医学院药学院药物化学硕士

·2002.9–2006.6 华中科技大学同济医学院药学院 生物药学 学士

工作经历

·2019.10至今 重庆医科大学副研究员

·2016.9–2019.9 重庆医科大学 助理研究员

·2014.1–2016.6 华中科技大学博士后

·2011.10–2013.10澳大利亚南澳大学助理研究员

主持项目

·国家自然科学基金面上项目，82071671，2021.1–2024.12，55万元，在研

·国家自然科学基金青年科学基金，81701477，2018.1–2020.12，18万元，结题

·超声医学国家重点实验室开放课题，2022KFKT022，2022.9–2024.5，10万元，在研

·中国博士后科学基金项目，2014M550396，2014.5–2016.10，8万元，结题

代表论文（2019-2024）

（1）Wu K#, Liu Y#, Xia J#, Liu J#, Wang K, Liang H, Xu F, Liu D, Nie D, Tang X, Huang A*,Chen C*, Tang N*. Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid. Adv Sci (Weinh). (2024);11(2):e2304408.

（2）Fang L, Zhai Q, Zhang H, Ji P,Chen C*, Zhang H*.Comparisons of different extraction methods and solvents for saliva samples.Metabolomics(2024) 9;20(2):38.

（3）Gou D#, Liu R#, Shan X#, Deng H#,Chen C#, Xiang J, Liu Y, Gao Q, Li Z, Huang A*, Wang K*, Tang N*. Gluconeogenic enzyme PCK1 supports S-adenosylmethionine biosynthesis and promotes H3K9me3 modification to suppress hepatocellular carcinoma progression. J Clin Invest. (2023);133(13):e161713.

（4）LiY, ZhangD, MoY, ZengT, WuT, LiuL, ZhangH*,ChenC*. Simultaneous determination of sex hormones and bile acids in rat plasma using a liquid chromatography- tandem mass spectrometry method. Journal of Pharmaceutical and Biomedical Analysis (2023), 115139.

（5）GaoQ#, ChengB#,ChenC#, LeiC#, LinX, NieD, LiJ, HuangL, LiX, WangK*, HuangA*, TangN*. Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signalling pathway Clinical and Translational Medicine (2022), 12(8): e995. doi: 10.1002/ctm2.995.

（6）Wang X#,Chen C#,Xie C, Huang W, Young RL, Jones KL, Horowitz M, Rayner CK, Sun Z*, Wu T*. Serum bile acid response to oral glucose is attenuated in patients with early type 2 diabetes and correlates with 2h plasma glucose in individuals without diabetes. Diabetes Obes Metab. (2022).doi: 10.1111/dom.14683.

（7）Zhu J#, Song G#, Zhou X, Han TL, Yu X, Chen H, Mansell T, Novakovic B, Baker PN, Cannon RD, Saffery R,Chen C*, Zhang H*. CD39/CD73 Dysregulation of Adenosine Metabolism Increases Decidual Natural Killer Cell Cytotoxicity: Implications in Unexplained Recurrent Spontaneous Abortion. Front Immunol. (2022).13:813218.

（8）Xiang J#,Chen C#, Liu R#, Gou D#, Chang L, Deng H, Gao Q, Zhang W, Tuo L, Pan X, Liang L, Xia J, Huang L, Yao K, Wang B, Hu Z, Huang A*, Wang K* & Tang N*. Gluconeogenic enzyme pck1 deficiency promotes chk2 o-glcnacylation and hepatocellular carcinoma growth upon glucose deprivation. J Clin Invest(2021), 131.

（9）Chen H#, Tang X#, Han TL, Zhu JN, Zhou W, Baker PN,Chen C* & Zhang H*. Potential role of foxo3a in the regulation of trophoblast development and pregnancy complications. J Cell Mol Med (2021), 25, 4363-4372.

（10）Xie J#,Chen C#, Hou LJ, Zhou CJ, Fang L* & Chen JJ*. Dual metabolomic platforms identified a novel urinary metabolite signature for hepatitis b virus-infected patients with depression. Diabetes Metab Syndr Obes(2020), 13, 1677-1683.

（11）Chen C*, Fan Z, Xu H, Tan X & Zhu M. Metabolomics-based parallel discovery of xenobiotics and induced endogenous metabolic dysregulation in clinical toxicology. Biomed Chromatogr(2019), 33, e4413.