王志鹏
博士（师资博士后），副研究员，邮箱：zp.wang@cqmu.edu.cn
教育工作经历
博士毕业于重庆大学药学院，随后进入中国科学院重庆绿色智能技术研究院任助理研究员，2022年12月入职重庆医科大学药学院开展博士后研究，主要研究方向为基于天然产物的抗菌/抗肿瘤药物设计、合成和活性研究。近年来，在Angw.Chem.，J. Med. Chem. 等国际知名期刊发表SCI论文10余篇，申请国家发明专利6项，已授权4项（转化1项）。主持国家自然科学基金青年基金、重庆市自然科学基金面上项目等多项科研项目，参与研究生《高等天然药物化学》课程教学。
承担科研项目
国家自然科学基金青年基金（2021）
重庆市自然科学基金面上项目（2020，2024）
重庆市博士后研究项目特别资助（2023）
重庆市重点实验室开放基金（2020）
代表性论文
1.C. Pan#, Q. Li#, S. Xiong, Y. Yang, Y. Yang, C. Huang*,Z.-P. Wang*, Delivery Strategies, Structural Modification, and Pharmacological Mechanisms of Honokiol: A Comprehensive Review,Chemistry & Biodiversity,2024,21, e202302032.
2.X. Yang#,Z.-P. Wang#, S. Xiang,D. Wang,Y. Zhao, Z. Zhao, Y. Qiu, J. Guo, Y. Dai, S. Zhang*, Y. He*,Optimization of natural product Calothrixin A to discover novel dual Topoisomerase I and II inhibitors with improved anticancer activity,J. Med. Chem.2022, 65, 11, 8040.
3. S.Zhao#,Z.-P. Wang#, Z. Lin#, G. Wei, X. Wen, S. Li, X. Yang, Y. Dai, J. Guo*, Yun He*, Drug Repurposing by Siderophore Conjugation: Design, Synthesis and Biological Evaluation of Siderophore-Methotrexate Conjugates as Antimicrobials.Angew. Chem., Int. Ed.,2022,61, e2022041.
4.A. Nazli, D. L. He,Z.-P. Wang*, Y. He*, A Comparative Insight on the Newly Emerging Rifamycins: Rifametane, Rifalazil, TNP-2092 and TNP-2198.Curr. Med. Chem.2022,29,2846.
5.B. Xu#,Z.-P. Wang#, X. H. Yang, Y. Qiu, S.- L. Zhang*, Y. He*.Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity.Eur. J. Med. Chem.,2021,214,113225.
6. H. Xu, A. Nazli, C. Zou,Z.-P. Wang*, Y. He*, Bench-stableimine surrogates for the one-pot and catalytic asymmetric synthesis of a-amino esters/ketones.Chem. Comm.,2020,56, 14243.
7.Z.-P. Wang, Q. Wu, J. Jiang, Z.-R. Li, X.-J. Peng, P.-L. Shao*, Y. He*, Catalytic Asymmetric Synthesis of Pyrrolidine Derivatives Bearing Heteroatom-Substituted Quaternary Stereocenters,Org. Chem. Front.,2018,5, 36.
8.Z.-P. Wang,S. Xiang, P.-L. Shao*, Y. He*, Catalytic Asymmetric [3 + 2] Cycloaddition Reaction Between Aurones and Isocyanoacetates: Access to SpiropyrrolinesviaSilver Catalysis,J. Org. Chem.,2018,83,10995.
9.Z.-P. Wang, Y. He, P.-L. Shao*, Transition-Metal-Free Synthesis of Polysubstituted Pyrrole DerivativesviaCyclization of Isocyanoacetates with Aurone Analogues,Org. Biomol. Chem.,2018,16, 5422.
10.Z.-P. Wang, Z.-R. Li, Q. Wu, X.-J. Peng, P.-L. Shao*, Y. He*, Enantioselective Synthesis of Alkylthioetherpyrrolidine Derivativesvia[3 + 2] Cycloaddition of α-Thioacrylates with Isocyanoacetates,J. Org. Chem.,2017,82,12869.
