温纯洁,女,副研究员,硕士生导师,2014年获重庆医科大学药学专业博士学位。主要致力于恶性肿瘤精准治疗及抗肿瘤药药物耐药产生机制、分子标志物及干预靶点研究。作为负责人承担了国家自然科学基金、重庆市自然科学基金等多项研究,以第一作者/通讯作者身份发表论文多篇。
联系方式:wenchunj@cqmu.edu.cn
主要研究方向:
1.抗肿瘤药物获得性耐药机制及干预策略研究;
2.恶性肿瘤的精准治疗。
代表性论文(#第一作者,*通讯作者)
1. Chunjie Wen#, Yaji Li, Yutang Huang, Nan Wang, Shuai He, Meihua Bao, Honghao Zhou, Lanxiang Wu*. CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway. Int J Biochem Cell Biol. 2023 Jan;154:106344.
2. Chunjie Wen#, Ge Xu, Shuai He, Yutang Huang, Jingjing Shi, Lanxiang Wu*, Honghao Zhou. Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines. J Cancer. 2020 Apr 6;11(13):3816-3826.
3. Wu Lanxiang, Wang Bin, Xu Ge, Huang Yutang, Wen Chunjie*, Zhou Honghao. Long-term exposure of 4-hydroxyestradiol induces the cancer cell characteristics via upregulating CYP1B1 in MCF-10A cells. Toxicol Mech Methods. 2019 Nov;29(9):686-692.
4. Chunjie Wen#, Lijuan Fu, Jiafeng Huang, Yi Dai, Bin Wang, Ge Xu, Lanxiang Wu*, Honghao Zhou. Curcumin reverses doxorubicin resistance via inhibition the efflux function of ABCB4 in doxorubicinresistant breast cancer cells. Mol Med Rep. 2019 Jun;19(6):5162-5168.