博士，特聘教授，博士生导师，国家级青年人才（海外）。
电子邮箱：yuebao.zhang@cqmu.edu.cn;yuebao.zhang@hotmail.com
个人简介：
2017年博士毕业于四川大学华西药学院，获理学博士学位。2018-2022年在俄亥俄州立大学药学院从事博士后研究。2024年入选国家级青年人才计划项目（海外）。2025年01月入职重庆医科大学药学院。主要从事用于mRNA精准递送的LNP以及mRNA-LNP药物的开发。迄今已发表学术论文20篇，其中以第一作者或共同第一作者在NatureNanotechnology，ChemicalReviews，AngewandteChemieInternationalEdition，NatureCommunications，PNAS，AdvancedMaterials，Nano Letters，AdvancedScience等国际顶级学术期刊发表论文十篇。作为共同发明人申请国内及国际发明专利12项。
教育及工作经历：
2007-2011年，郑州大学，理学学士
2011-2014年，四川大学，理学硕士（导师：宋振雷教授）
2014-2017年，四川大学，理学博士（导师：宋振雷教授）
2018-2022年，俄亥俄州立大学，博士后（合作导师：董一洲教授）
2023-2024年，深圳厚存纳米药业有限公司，化学总监
2025年01月至今，重庆医科大学药学院，特聘教授，博士生导师
研究方向：
用于mRNA高效精准递送的LNP的研究；
新型mRNA-LNP疗法的开发。
热烈欢迎对mRNA递送载体和mRNA疗法相关研究感兴趣的同学加入课题组！
代表性论文（#代表共同第一作者）：
1.Yuebao Zhang#, Xucheng Hou#, Shi Du#, Yonger Xue, Jingyue Yan, Diana D. Kang, Yichen Zhong, Chang Wang, Binbin Deng, David W. McComb, Yizhou Dong* "Close the Cancer-Immunity Cycle by integrating lipid nanoparticle-mRNA formulations and cell therapy to promote tumor elimination and develop long-term antitumor immunity"Nat.Nanotechnol.2023, 18, 1364-1374.
2.Yuebao Zhang, Changzhen Sun, Chang Wang, Kartarina E. Jankovic, Yizhou Dong* "Lipids and Lipid Derivatives for RNA Delivery"Chem.Rev.2021, 121(20), 12181-12277.
3.Yuebao Zhang, Qianyou Guo, Ji Lu, Xianwei Sun, Lu Gao and Zhenlei Song* "Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy"Angew. Chem. Int. Ed.2018, 57(4), 942-946. [Highlighted inSYNFACTS2018, 14(03), 0226.]
4.Yuebao Zhang#, Jingyue Yan#, Xucheng Hou, Chang Wang, Diana D. Kang, Yonger Xue, Shi Du, Binbin Deng, David W. McComb, Shan-Lu Liu, Yichen Zhong, and Yizhou Dong* "STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV-2"Nano Lett.2023, 23(7), 2593-2600.
5.Yonger Xue#,Yuebao Zhang#, Yichen Zhong#, Shi Du, Xucheng Hou, Wenqing Li, Haoyuan Li, Siyu Wang, Chang Wang, Jingyue Yan, Diana D. Kang, Binbin Deng, David W. McComb, Darrell J. Irvine, Ron Weiss, Yizhou Dong* "LNP-RNA-engineered adipose stem cells for accelerated diabetic wound healing"Nat. Commun.2024, 15, 739.
6.Siyu Wang#,Yuebao Zhang#,Yichen Zhong#,Yonger Xue,Zhengwei Liu,ChangWang,Diana. Kang,Haoyuan Li, Xucheng Hou, Meng Tian, Dinglingge Cao, Leiming Wang, Kaiyuan Guo, Binbin Deng, David W. McComb, Miriam Merad, Brian D. Brown,Yizhou Dong*"Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation"Proc. Natl. Acad. Sci. U.S.A.2024, 121(22), e2322935121.
7.Jingyue Yan#,Yuebao Zhang#, Shi Du#, Xucheng Hou, Wenqing Li, Chunxi Zeng, Chengxiang Zhang, Binbin Deng, David W. McComb, Weiyu Zhao, Yonger Xue, Diana D. Kang, Yizhou Dong* "Nanomaterials-Mediated Co-stimulation of Toll-Like Receptors and CD40 for Antitumor Immunity"Adv. Mater.2022, e2207486.
8.Shi Du#, Wenqing Li#,Yuebao Zhang#, Yonger Xue, Xucheng Hou, Jingyue Yan, Jeffrey Cheng, Binbin Deng, David McComb, Jennifer Lin, Hong Zeng, Xiaolin Cheng, Darrell Irvine, Ron Weiss, Yizhou Dong* "Cholesterol-amino-phosphate (CAP) derived lipid nanoparticles for delivery of self-amplifying RNA and restoration of spermatogenesis in infertile mice"Adv. Sci.2023, 2300188.
9.Yuebao Zhang, Ji Lu, Hongze Li, Xianwei Sun, Lu Gao,Zhenlei Song* "Total Synthesis of Bryostatin 8 and (–)-Exiguolide: Applications of an Organosilane Strategy"Synlett2019, 30(07), 753-764.
10.Changzhen Sun#,Yuebao Zhang#, Peihong Xiao, Hongze Li, Xianwei Sun, Zhenlei Song* "Intramolecular [1,4]-S- to O-Silyl Migration: A Useful Strategy for Synthesizing Z-Silyl Enol Ethers with Diverse Thioether Linkages"Org. Lett.2014, 16, 984-987.
