周辉，男，博士，教授，硕导。
1998.9-2002.7四川大学化学学院 化学专业学习 获学士学位
2002.9-2005.7四川大学化学学院 有机化学专业学习 获硕士学位（导师：冯小明院士）
2005.9-2008.7四川大学化学学院 有机化学专业学习 获博士学位（导师：冯小明院士）
2008.7-至今重庆医科大学药学院工作
2008.11-2013.5重庆医科大学药学院药学博士后流动站（合作导师：李勤耕教授）
ORCID:0000-0001-7018-3277
研究方向：
手性技术与手性药物研究、不对称合成及手性药物新工艺研究
研究方向简介：手性药物是手性技术应用最广泛、效果最显著的领域。目前手性药物占世界上使用药物的50%以上，全球手性药物市场已达数千亿美元，说明了该领域的重要性。我们小组着力发展不对称合成新方法、新技术，为手性药物及中间体的合成提供新方法、新工艺，为新型手性先导化合物的发现提供研究基础。
代表性论文：
23) Qian Pu, Mingming Huo, Guojuan Liang, Lijuan Bai, Genhui Chen, Hongjiao Li, Peng Xiang,Hui Zhou*and Jing Zhou*, “Divergent oxidative dearomatization coupling reactions to construct polycyclic cyclohexadienones”Chem. Commun.2022,58, 4348-4351.
22) Zinan Yang, Huakang He, Rui Tian, Ruoran Wu, Sheng Hu, Yue Wu*, andHui Zhou*, “A zinc/PyBisulidine catalyzed asymmetric Mannich reaction ofN-tosyl imines with 3-acyloxy-2-oxindoles”Org. Biomol. Chem.2021,19, 7460-7469.
21) Huakang He, Zinan Yang, Yu Chai, Ruoran Wu, Peng Chen, Jing Zhou*, andHui Zhou*,“Reversal of Enantioselectivity in the Copper-Aminophenol Sulfonamide Catalyzed Alkynylation of Isatins by Slightly Tuning the Ligand Structure and Basic Additives”Org. Lett.2021,23, 5739-5743.
20)Yuchen Yang, Cheng Tang, Guojuan Liang, Ping Deng, Jing Zhou, Zinan Yang, Peng Chen, andHui Zhou*, “Cooperative Heterobimetallic Zinc/Alkaline Earth Metal Catalysis: A Zn/Sr Aminophenol Sulfonamide Complex for Catalytic Asymmetric Michael Addition of 3‑Acetoxy-2-oxindoles to β‑Ester Enones”J. Org. Chem.2021,86, 7119-7130.
19)Chuanlong Xu, Yuchen Yang, Yue Wu, Feilong He, Huakang He, Ping Deng* andHui Zhou*, “Development of TsDPEN based imine-containing ligands for the copper-catalysed asymmetric Kinugasa reaction”RSC Adv.2020,10, 18107-18114.
18)Jing Zhou, Li-Juan Bai, Guo-Juan Liang, Qi-Gui Xu, Li-Ping Zhou andHui Zhou*, “Organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substitutedp-QMs with α-nitroketones”Org. Biomol. Chem.2020,18, 2641-2645.
17) Mouxiong Liu, Dongdong Gui, Ping Deng andHui Zhou*, “Asymmetric Henry Reaction of 2-AcylpyridineN-Oxides Catalyzed by a Ni-Aminophenol Sulfonamide Complex: An Unexpected Mononuclear Catalyst”Molecules2019,24, 1471.
16) Junhao Jiang,Hui Zhou, Qihua Jiang, Lili Sun and Ping Deng*, “Novel Transforming Growth Factor-Beta Receptor 1 Antagonists through a Pharmacophore-Based Virtual Screening Approach”Molecules2018,23, 2824.
15) Guanghui Chen, Guojuan Liang, Yiwu Wang, Ping Deng,Hui Zhou*, “A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins”Org. Biomol. Chem.2018,16, 3841-3850.
14) Feilong He, Guanghui Chen, Junxia Yang, Guojuan Liang, Ping Deng, Yan Xiong,Hui Zhou*, “Catalytic enantioselective Henry reaction ofα-ketoesters, 2-acylpyridines and 2-acylpyridineN-oxides”RSC Adv.2018,8, 9414-9422.
13) Jing Zhou, Guojuan Liag, Xiangnan Hu, Liping Zhou,Hui Zhou*, “Facile synthesis of 3-aryl 2,3-dihydrobenzofurans via novel domino 1,6-addition/O-alkylation reactions of para-quinone methides”Tetrahedron,2018,74, 1492-1496.
12) Shixiong Zhang, Ping Deng, Jing Zhou, Mouxiong Liu, Guojuan Liang, Yan Xiong,Hui Zhou*, “A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale”Chem. Commun.2017,53, 12914-12917. (Highlighted bySynfacts,2018,14, 285)
11) Youmao Zeng, Ping Deng, Shixiong Zhang, Hong Yan, Guojuan Liang, Yan Xiong,Hui Zhou*, “An Ni-PyBisulidine Complex for the Asymmetric Hydrophosphonylation of Aldehydes”Org. Biomol. Chem.2016,14, 9221-9224.
10) Yang Li, Ping Deng, Youmao Zeng, Yan Xiong,Hui Zhou*, “anti-Selective Asymmetric Henry Reaction Catalyzed by a Heterobimetallic Cu-Sm-Aminophenol Sulfonamide Complex”Org. Lett.2016,18, 1578-1581.
9) Yajun Liu, Ping Deng, Xiangyang Li, Yan Xiong,Hui Zhou*, “Asymmetric Henry Reaction Catalyzed by a Chiral Dinuclear Nickel Complex”Synlett,2014,25, 1735-1738. (Highlighted bySynfacts,2014,10, 1045)
8) Tao Wang, Rui Tian, Bin Xiao, Yi Shen,Hui Zhou*, Qingeng Li*, “A Novel Synthesis of Ibutilide Fumarate”Lett. Org. Chem.2011,8, 423-426.
7)Hui Zhou, Dahai Chen, Hongwei Gao, Qingeng Li*, “A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III”Lett. Org. Chem.,2010,7,450-452.
6)Hui Zhou, Dan Peng, Bo Qin, Zongrui Hou, Xiaohua Liu, Xiaoming Feng*, “Highly Enantioselective Aza Henry Reaction ofN-tosyl imines Catalyzed byN,N-dixoide-Cu(I) Complex”J. Org. Chem.,2007,72,10302-10304.
5) Dan Peng,Hui Zhou, Xiaohua Liu, Liwei Wang, Shikui Chen, Xiaoming Feng* “Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Chiral Quaternary Ammonium Salt and Triethylamine”Synlett,2007,15, 2448–2450.
4) Shi-Kui Chen, Dan Peng,Hui Zhou, Li-Wei Wang, Fu-Xue Chen, Xiao-Ming Feng* “Highly Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Mononuclear Salen-Ti(OiPr)4Complex Produced In Situ”Eur. J. Org. Chem.2007, 639–644.
3) Fu-Xue Chen,Hui Zhou, Xiaohua Liu, Bo Qin, Xiaoming Feng*, Guolin Zhang, Yaozhong Jiang, “Enantioselective Cyanosilylation of Ketones by a Catalytic Double Activation Method with an Aluminium Complex and anN-Oxide”Chem. Eur. J.2004,10, 4790 – 4797.
2) Fu-Xue Chen, Xiaohua Liu, Bo Qin,Hui Zhou, Xiaoming Feng*, Guolin Zhang, “Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins”Synthesis2004,14, 2266–2272.
1)Hui Zhou, Fuxue Chen, Bo Qin, Xiaoming Feng*, Guolin Zhang, “Cyanosilylation of Ketones Catalyzed by Quaternary Ammonium Salt andN-oxide”Synlett,2004, 1077-1079.
专利：
1)周辉，张仕雄，邓萍，刘谋雄，梁国娟，黎洋，手性氨基磺酰胺配体金属络合物及其在催化反应中的应用，专利号：ZL201710962089.3，授权公告日：2020年12月25日，授权公告号：CN109666049 B.
2)周辉，何华康，周静，邓萍，梁国娟，单手性臂氨基酚磺酰胺配体及在不对称催化中的应用，申请号：202110715362.9，申请公布日：2021年9月28日。
主持课题
7)重庆市自然科学基金面上项目（cstc2019jcyj-msxmX0034，负责人）
6)重庆市教委科技项目青年项目（KJQN201900437，负责人）
5)国家自然科学基金面上项目（21672031，负责人，已结题）
4)重庆市教委科技项目（KJ1500221，负责人，已结题）
3）药学院青年师资培养项目（YXY2014QNSZ01，负责人，已结题）
2)重庆市科委基础与前沿研究一般项目 （cstc2013jcyjA10144,负责人，已结题）
1)国家自然科学基金青年项目（20902114，负责人，已结题）
E-mail：hzhou@cqmu.edu.cn
