赵倩倩，女，副教授，硕士生导师。
邮箱：zhaoqianqian423@163.com
教育工作经历：
本硕毕业于沈阳药科大学，博士毕业于澳门大学，后赴德国于利息研究中心进行博士后研究。入选“中德博士后人才项目”“重庆英才计划”。现主要从事药物递送系统的分子动力学模拟研究、以及人工智能驱动药物制剂处方的开发。在药学和计算领域权威期刊Acta Pharmaceutical Sinica B、Food Hydrocolloids、Asian Journal of Pharmaceutical Sciences、Journal of Chemical Theory and Computation等发表论文十余篇。近年来主持和参与国家自然科学基金、重庆市自然科学基金等多项科研项目。同时承担《药剂学》、《生物技术药物药剂学》、《药学英语》、《计算机辅助药物》等课程的教学工作。
研究方向：
1．药物递送系统和生物体系的分子动力学模拟研究
2．人工智能驱动药物制剂处方的开发
3．难溶性药物增溶的开发及产业化研究
4．新型纳米药物递送系统
科研项目：
1.国家自然科学基金委员会，青年项目，2023.01-2025.12，在研，主持。
2.重庆市教委科学技术研究计划，青年项目，2024.10-2027.09，在研，主持。
3.重庆市博士后留(来)渝资助项目，人才项目，2024.01-2026.12，在研，主持。
4.重庆医科大学校级科研人才引进启动项目，2021.11-2025.11，在研，主持。
5.国家自然科学基金委员会，面上项目，2022.01-2025-12,在研,参与。
6.重庆市自然科学基金委员会，面上项目，2022.08–2025.07，在研，参与。
7.重庆医科大学未来医学青年创新团队支持计划,校级, 2022.02–2025.01，在研，参与。
代表性科研成果（一作/通讯）：
1. Pu Zheng1, Xinru Chen1, Chunyang Zhao, Jialong Wang, Jianhong Zhang, Xiong Hu, Wenchao Geng,Qianqian Zhao*.Integrating strategy to investigate the formation and stabilization mechanisms of Curcumin-Cyclodextrin inclusion complexes: Experimental characterizations and multi-scale computational simulations.Food Hydrocolloids, 2025, 159:110679.(IF=11.0，中科院1区)
2. Qianqian Zhao, Riccardo Capelli, Paolo Carloni, Bernhard Lüscher, Jinyu Li, Giulia Rossetti*;An Enhanced Sampling Approach to the Induced Fit Docking Problem in Protein-Ligand Binding: the case of mono-ADP-ribosylation hydrolases inhibitors.Journal of Chemical Theory and Computation, 2021,17,7899-7911.(IF=5.7，中科院1区)
3. Qianqian Zhao, Zhuyifan Ye, Yan Su, Defang Ouyang*; Predicting complexation performance between cyclodextrins and guest molecules by integrated machine learning and molecular modeling techniques,Acta Pharmaceutical Sinica B, 2019, 9(6): 1241-1252.(IF=14.7，中科院1区)
4. Tianhe Huang#,Qianqian Zhao#,Yan Su, Defang Ouyang*;Investigation of molecular aggregation mechanism of glipizide/cyclodextrin complexation by combined experimental and molecular modeling approaches,Asian Journal of Pharmaceutical Sciences, 2019, 14: 609-620.(IF=10.7，中科院1区，共同1作)
5. Qiang Li#,Qianqian Zhao#,Qiufang Jing, Xiaosi Ma, Ning Chen, Guobin Ren, Defang Ouyang*, Fuzheng Ren*;Investigating molecular interactions of high-loaded glipizide-HPMCAS microparticles by integrated experimental and modeling techniques,European Journal of Pharmaceutical Sciences, 2019. 131: p. 127-135.(IF=4.3，共同1作)
6. Qianqian Zhao, Haoshi Gao, Yan Su, Tianhe Huang, Jiahong Lu, Hua Yu, Defang Ouyang*; Experimental characterization and molecular dynamic simulation of ketoprofen-cyclodextrin complexes,Chemical Physics Letters, 2019, 736: p. 136802.(IF=2.8)
7. Qianqian Zhao, Nikhila Miriyala, Yan Su, Defang Ouyang*, et al.;Computer-aided formulation design for a highly-soluble lutein-cyclodextrin multiple-component delivery system,Molecular pharmaceutics,2018, 15: 1664-1673.(IF=4.5，中科院2区)
8. Qianqian Zhao,Weixiang Zhang, Runmiao Wang, Yitao Wang, Defang Ouyang*; Research Advances on Molecular Modeling in Cyclodextrins,Current pharmaceutical design,2017. 23(3): p. 522-531.(IF=2.6)
9. Weixiang Zhang#,Qianqian Zhao#,Junling Deng, Yuanjia Hu, Yitao Wang,Defang Ouyang*;Big Data Analysis of Global Advances in Pharmaceutics and Drug Delivery from 1980–2014.Drug Discovery Today, 2017, 22(8): 1201-1208.(IF=6.5,中科院2区，共同1作)
参与发表论文：
1. Song Xie, Shoujing Cao, Juhong Wu, Zhinuo Xie, Yu-Tsen Liu, Wei Fu,Qianqian Zhao, Lin Liu, Lin Yang, Jinyu Li*. In silico-based screening of natural products as potential inhibitors of SARS-CoV-2 macrodomain 1.Journal of Biomolecular Structure and Dynamics.2024. 42(10): p. 5229-5237.
2. Tang Gao, Luyang Yi, Yihui Wang, Wenyuan Wang,Qianqian Zhao, Yuan Song, Mengdan Ding, Cheng Deng, Yihan Chen, Yuji Xie, Wenqian Wu, Qiaofeng Jin, Li Zhang*, Mingxing Xie*.Granzyme B-responsive fluorescent probe for non-invasive early diagnosis of transplant rejection.Biosensors and Bioelectronics, 2023. 232: p. 115303.
3. Tang Gao1, Huiling Li1, Ya Wu, Cheng Deng, Yuji Xie, Jing Wang, Yali Yang, Qin Lv, Qiaofeng Jin, Yihan Chen, Luyang Yi, Yi Zhong, Xueke Li,Qianqian Zhao, Li Zhang*, Mingxing Xie*. First aggregation-induced emission-active probe for species-specific detection ofβ-galactosidase.Talanta, 2021. 235: p. 122659.
4. Wei Fu, Huiqiao Yao, Mareike Bütepage,Qianqian Zhao, Bernhard Lüscher,Jinyu Li*. The search for inhibitors of macrodomains for targeting the readers and erasers of mono-ADP-ribosylation.Drug Discovery Today, 2021. 26(11): p. 2547-2558.
5. Zhaoxi Sun*, Xiaohui Wang, Qianqian Zhao, Tong Zhu. Understanding Aldose Reductase-Inhibitors interactions with free energy simulation.Journal of Molecular Graphics and Modelling. 2019. 91: p. 10-21.
6. Yilong Yang, Zhuyifan Ye, Yan Su,Qianqian Zhao, Xiaoshan Li, Defang Ouyang*.Deep learning for in vitro prediction of pharmaceutical formulations.Acta Pharmaceutical Sinica B,2019. 9(1): p. 177-185.
7. Fei Li, Shuangshuang Song, Yingxin Guo,Qianqian Zhao, Xuemei Zhang, Weisan Pan*, Xinggang Yang*. Preparation and pharmacokinetics evaluation of oral self-emulsifying system for poorly water-soluble drug Lornoxicam.Drug Delivery, 2015. 22(4): p. 487-498.
8. Shujuan Li, Xiaoyu Wang, Yingying Wang,Qianqian Zhao, Lina Zhang, Xinggang Yang, Dandan Liu*, Weisan Pan*. A novel osmotic pump-based controlled delivery system consisting of pH-modulated solid dispersion for poorly soluble drug flurbiprofen: in vitro and in vivo evaluation.Drug Development and Industrial Pharmacy, 2015. 41(12): p. 2089-2099.
申请专利：
1.赵倩倩，王佳龙，张健红；一种含吡罗昔康的固体分散体及制备方法，申请号：CN202410969109.X（申请日期：2024.07.18）
2.欧阳德方*,赵倩倩，含有叶黄素的药物组合物及其制备方法和制剂。专利申请号：CN 201710355210.6.（申请日期：2017.05.19）
3.欧阳德方*,赵倩倩，一种药物制剂处方虚拟设计及评估的方法和系统。专利申请号：CN201710429764.6（申请日期：2017.06.05）
4.杨星钢，梁静阁，朱志红，赵倩倩，潘卫三，银杏内酯控释片及制备方法。专利号：ZL201310575789.9（授权日期：2016.03.02）
5.杨星钢，梁静阁，朱志红，赵倩倩，潘卫三，银杏内酯双层渗透泵控释片及制备方法。专利号：ZL201310575814.3（授权日期：2015.12.30）
团队建设：
作为重庆医科大学高层次引进人才特聘副教授，已搭建独立的“药物递送系统计算平台”，能够支撑开展各类计算药剂学相关研究。现团队有硕士研究生6人。团队重视研究生综合素质和能力培养，指导研究生获得重庆市研究生科研创新项目1项，研究生国家奖学金1项，2024年指导研究生和本科生团队获得“东富龙-国药工程杯”第十二届全国大学生制药工程设计竞赛二等奖。
