李文曦，重庆医科大学，特聘副教授，硕士研究生导师

邮箱：103380@cqmu.edu.cn

教育工作经历：

2024-12至今，重庆医科大学药学院，特聘副教授，硕士研究生导师

2023-08至2024-11，澳门大学健康科学学院，博士后（合作导师：代云路教授）

2023-04至2023-07，澳门大学健康科学学院，科研助理（合作导师：代云路教授）

2019-08至2023-03，澳门大学健康科学学院，生物医药，博士（导师：代云路教授）

2016-08至2019-06，重庆大学药学院，药学，硕士（导师：贺耘教授）

2012-08至2016-06，吉林大学药学院，药学，学士

研究方向：

p探究基于金属多酚配位纳米体系的肿瘤精准靶向纳米医学治疗体系，包括靶基修饰、功能性金属离子递送等。

p探究基于细菌开发的交叉反应性肿瘤免疫治疗体系，包括细菌外膜泡及活性细菌治疗等肿瘤疫苗的开发。

n旨在开发具有转化前景的纳米医学药物，如用于靶向递送、放疗增敏、多模态生物成像和免疫调节等特异性一体化纳米治疗体系。

代表性论著：

1.W.Li, …, and Y. Dai*.Magnesium-Phenolic Nanoeditor Refining Gliomatous T Cells for Metalloimmunotherapy.ACS Nano(IF15.8, Q1)

2.W.Li, …, and Y. Dai*. A Platinum@Polymer-Catechol Nanobraker Enables Radio-Immunotherapy for Crippling Melanoma Tumorigenesis, Angiogenesis, and Radioresistance.Bioactive Materials22, 34-46 (2023). (IF 18.0, Q1)

3.W. Li, …, and Y. Dai^*. A “Three Musketeers” Tactic for Inclining Interferon-γ as a Comrade-in-Arm to Reinforce the Synergistic-Tumoricidal Therapy.Nano Research15, 3458–3470 (2022). (IF 9.5, Q1)

4.W. Li,…,Y. He^*,andC. Wang^*.Inhalable Functional Mixed-Polymer Microspheres to Enhance Doxorubicin Release Behavior for Lung Cancer Treatment.Colloids and Surfaces B: Biointerfaces196, 111350-111358 (2020).(IF 5.4, Q2)

5.H. Tian,W. Li (Co-first author), …, and Y. Dai*. Phenolic nanomaterial with organelle-level precision primes anti-tumor immunity via mtDNA-dependent cGAS-STING activation.Angewandte Chemie International Editione202411498.(IF 16.1, Q1)

6.J. Yan,W. Li (Co-first author), …, and Y. Dai*. Metal-Phenolic Nanomedicines Regulate T-Cell Antitumor Function for Sono-Metabolic Cancer Therapy.ACS Nano17, 14667-14677 (2023). (IF 15.8, Q1)

7.H. Tian,W. Li(Co-first author), …, and Y. Dai*. Self-Degradable Nanogels Reshape Immunosuppressive Tumor Microenvironment via Drug Repurposing Strategy to Reactivate Cytotoxic CD8⁺T Cells.Advanced Sciences10,2301661 (2023). (IF 14.3, Q1)

8.J. Li,W. Li(Co-first author), …, and Y. Dai^*. A Metal–Polyphenolic Nanosystem with NIR-II Fluorescence-Guided Combined Photothermal Therapy and Radiotherapy.Chemical Communications57, 11473-11476 (2021). (IF 4.3, Q2)

9.C. Jiang,W. Li,…, and Y. Dai^*.A robust ROS generation and ferroptotic lipid modulation nanosystem for mutual reinforcement of ferroptosis and cancer immunotherapy.Advanced Healthcare Materials(IF 10.0, Q1)

10.Y. Feng, G. Wang,W. Li, …, Y. Dai (2023). PhotoPyro‐induced cGAS‐STING Pathway Activation Enhanced Anti‐Melanoma Immunotherapy via a Manganese‐Coordinated Nanomedicine.Advanced Healthcare Materials2302811 (2023). (IF 10.0, Q1)

11.Z. Zhang,W.Sang, L. Xie,W. Li, …, and Y. Dai*. Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment.Angewandte Chemie International Edition60, 1967-1975 (2021). (IF 16.1, Q1)

12.J. Li, L. Xie, W. Sang,W. Li, …, and Y. Dai*. A Metal-Phenolic Nanosensitizer Performs Hydrogen Sulfide-Reprogrammed Oxygen Metabolism for Cancer Radiotherapy Intensification and Immunogenicity.Angewandte Chemie International Edition61, 202200830 (2022). (IF 16.1, Q1)

13.代云路，李文曦.金属配体纳米T细胞调节药物及其制备方法和抗脑瘤药物.(专利申请号：2024102441322)

14.贺耘，郭键，施伦瓦斯.邦尼，普拉巴卡尔.雷迪，李文曦，王晨晖.天然产物Dicododendrin及其衍生物的合成及应用.CN: CN109422750A, 2019-03-05. (专利)