周辉，男，博士，教授，硕导。
1998.9-2002.7四川大学化学学院 化学专业学习 获学士学位
2002.9-2005.7四川大学化学学院 有机化学专业学习 获硕士学位（导师：冯小明教授）
2005.9-2008.7四川大学化学学院 有机化学专业学习 获博士学位（导师：冯小明教授）
2008.7-至今重庆医科大学药学院工作
2008.11-2013.5重庆医科大学药学院药学博士后流动站（合作导师：李勤耕教授）
ORCID:0000-0001-7018-3277
研究方向：
手性技术与手性药物研究、不对称合成及手性药物新工艺研究
研究方向简介：手性药物是手性技术应用最广泛、效果最显著的领域。目前手性药物占世界上使用药物的50%以上，全球手性药物市场已达数千亿美元，说明了该领域的重要性。我们小组着力发展不对称合成新方法、新技术，为手性药物及中间体的合成提供新方法、新工艺，为新型手性先导化合物的发现提供研究基础。
代表性论文：
1. Gen-Hui Chen, Ying Ye, De-Xin Zhang, Hong-Jiao Li, Ning Zhang, Guo-Juan Liang, Dong Zhang,* Jing Zhou * andHui Zhou*, “Pd-catalyzed enantioselective [4 + 4] dipolar cycloaddition of aliphatic 1,4-dipoles with azadienes to access eight-memberedN-heterocycles”Org. Chem. Front.2023, Advance Article, DOI:10.1039/D3QO01089A.
2. Ruoran Wu, Peng Chen, Yu Chai, Junyu Zhou, Jianhua Ou, Yan Min, Haoting Wang, Guojuan Liang, Dong Zhang, Jing Zhou andHui Zhou*, “High diastereo- and enantioselective Michael addition of 3-acetoxy-2-oxindoles with nitroalkenes catalyzed by nickel/PyBisulidine”Org. Biomol. Chem.2023,21, 6225-6229.
3. Genhui Chen, Hongjiao Li, Guojuan Liang, Qian Pu, Lijuan Bai, Dexin Zhang, Ying Ye, Yong Li, Jing Zhou* andHui Zhou*, “Facile construction of dibenzodioxo[3.3.1]nonanes bearing spirocyclohexadienonesviadomino [4+2] cycloaddition/C(sp3)–H oxidative dehydrogenation coupling reactions”Org. Biomol. Chem.2022,20, 9392-9396.
4. Dan Meng, Jiali Xie, Yihao Li, Ruoyu Li,Hui Zhou*and Ping Deng*, “Structure-Guide Design and Optimization of Potential Druglikeness Inhibitors for TGFβRI with the Pyrrolopyrimidine Scaffold”Pharmaceuticals2022,15, 1264.
5. Qian Pu, Mingming Huo, Guojuan Liang, Lijuan Bai, Genhui Chen, Hongjiao Li, Peng Xiang,Hui Zhou*and Jing Zhou*, “Divergent oxidative dearomatization coupling reactions to construct polycyclic cyclohexadienones”Chem. Commun.2022,58, 4348-4351.
6. Zinan Yang, Huakang He, Rui Tian, Ruoran Wu, Sheng Hu, Yue Wu*, andHui Zhou*, “A zinc/PyBisulidine catalyzed asymmetric Mannich reaction ofN-tosyl imines with 3-acyloxy-2-oxindoles”Org. Biomol. Chem.2021,19, 7460-7469.
7. Huakang He, Zinan Yang, Yu Chai, Ruoran Wu, Peng Chen, Jing Zhou*, andHui Zhou*,“Reversal of Enantioselectivity in the Copper-Aminophenol Sulfonamide Catalyzed Alkynylation of Isatins by Slightly Tuning the Ligand Structure and Basic Additives”Org. Lett.2021,23, 5739-5743.
8. Yuchen Yang, Cheng Tang, Guojuan Liang, Ping Deng, Jing Zhou, Zinan Yang, Peng Chen, andHui Zhou*, “Cooperative Heterobimetallic Zinc/Alkaline Earth Metal Catalysis: A Zn/Sr Aminophenol Sulfonamide Complex for Catalytic Asymmetric Michael Addition of 3‑Acetoxy-2-oxindoles to β‑Ester Enones”J. Org. Chem.2021,86, 7119-7130.
9. Chuanlong Xu, Yuchen Yang, Yue Wu, Feilong He, Huakang He, Ping Deng* andHui Zhou*, “Development of TsDPEN based imine-containing ligands for the copper-catalysed asymmetric Kinugasa reaction”RSC Adv.2020,10, 18107-18114.
10. Jing Zhou, Li-Juan Bai, Guo-Juan Liang, Qi-Gui Xu, Li-Ping Zhou andHui Zhou*, “Organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substitutedp-QMs with α-nitroketones”Org. Biomol. Chem.2020,18, 2641-2645.
11. Mouxiong Liu, Dongdong Gui, Ping Deng andHui Zhou*, “Asymmetric Henry Reaction of 2-AcylpyridineN-Oxides Catalyzed by a Ni-Aminophenol Sulfonamide Complex: An Unexpected Mononuclear Catalyst”Molecules2019,24, 1471.
12. Junhao Jiang,Hui Zhou, Qihua Jiang, Lili Sun and Ping Deng*, “Novel Transforming Growth Factor-Beta Receptor 1 Antagonists through a Pharmacophore-Based Virtual Screening Approach”Molecules2018,23, 2824.
13. Guanghui Chen, Guojuan Liang, Yiwu Wang, Ping Deng,Hui Zhou*, “A homodinuclear cobalt complex for the catalytic asymmetric Michael reaction of β-ketoesters to nitroolefins”Org. Biomol. Chem.2018,16, 3841-3850.
14. Feilong He, Guanghui Chen, Junxia Yang, Guojuan Liang, Ping Deng, Yan Xiong,Hui Zhou*, “Catalytic enantioselective Henry reaction ofα-ketoesters, 2-acylpyridines and 2-acylpyridineN-oxides”RSC Adv.2018,8, 9414-9422.
15. Jing Zhou, Guojuan Liag, Xiangnan Hu, Liping Zhou,Hui Zhou*, “Facile synthesis of 3-aryl 2,3-dihydrobenzofurans via novel domino 1,6-addition/O-alkylation reactions of para-quinone methides”Tetrahedron,2018,74, 1492-1496.
16. Shixiong Zhang, Ping Deng, Jing Zhou, Mouxiong Liu, Guojuan Liang, Yan Xiong,Hui Zhou*, “A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale”Chem. Commun.2017,53, 12914-12917. (Highlighted bySynfacts,2018,14, 285)
17. Youmao Zeng, Ping Deng, Shixiong Zhang, Hong Yan, Guojuan Liang, Yan Xiong,Hui Zhou*, “An Ni-PyBisulidine Complex for the Asymmetric Hydrophosphonylation of Aldehydes”Org. Biomol. Chem.2016,14, 9221-9224.
18. Yang Li, Ping Deng, Youmao Zeng, Yan Xiong,Hui Zhou*, “anti-Selective Asymmetric Henry Reaction Catalyzed by a Heterobimetallic Cu-Sm-Aminophenol Sulfonamide Complex”Org. Lett.2016,18, 1578-1581.
19. Yajun Liu, Ping Deng, Xiangyang Li, Yan Xiong,Hui Zhou*, “Asymmetric Henry Reaction Catalyzed by a Chiral Dinuclear Nickel Complex”Synlett,2014,25, 1735-1738. (Highlighted bySynfacts,2014,10, 1045)
20. Tao Wang, Rui Tian, Bin Xiao, Yi Shen,Hui Zhou*, Qingeng Li*, “A Novel Synthesis of Ibutilide Fumarate”Lett. Org. Chem.2011,8, 423-426.
21. Hui Zhou, Dahai Chen, Hongwei Gao, Qingeng Li*, “A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III”Lett. Org. Chem.,2010,7,450-452.
22. Hui Zhou, Dan Peng, Bo Qin, Zongrui Hou, Xiaohua Liu, Xiaoming Feng*, “Highly Enantioselective Aza Henry Reaction ofN-tosyl imines Catalyzed byN,N-dixoide-Cu(I) Complex”J. Org. Chem.,2007,72,10302-10304.
23. Dan Peng,Hui Zhou, Xiaohua Liu, Liwei Wang, Shikui Chen, Xiaoming Feng* “Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Chiral Quaternary Ammonium Salt and Triethylamine”Synlett,2007,15, 2448–2450.
24. Shi-Kui Chen, Dan Peng,Hui Zhou, Li-Wei Wang, Fu-Xue Chen, Xiao-Ming Feng* “Highly Enantioselective Cyanoformylation of Aldehydes Catalyzed by a Mononuclear Salen-Ti(OiPr)4Complex Produced In Situ”Eur. J. Org. Chem.2007, 639–644.
25. Fu-Xue Chen,Hui Zhou, Xiaohua Liu, Bo Qin, Xiaoming Feng*, Guolin Zhang, Yaozhong Jiang, “Enantioselective Cyanosilylation of Ketones by a Catalytic Double Activation Method with an Aluminium Complex and anN-Oxide”Chem. Eur. J.2004,10, 4790 – 4797.
27. Fu-Xue Chen, Xiaohua Liu, Bo Qin,Hui Zhou, Xiaoming Feng*, Guolin Zhang, “Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins”Synthesis2004,14, 2266–2272.
27. Hui Zhou, Fuxue Chen, Bo Qin, Xiaoming Feng*, Guolin Zhang, “Cyanosilylation of Ketones Catalyzed by Quaternary Ammonium Salt andN-oxide”Synlett,2004, 1077-1079.
专利：
1. 周辉，张仕雄，邓萍，刘谋雄，梁国娟，黎洋，手性氨基磺酰胺配体金属络合物及其在催化反应中的应用，专利号：ZL201710962089.3，授权公告日：2020年12月25日，授权公告号：CN109666049 B.
2. 周辉，何华康，周静，邓萍，梁国娟，单手性臂氨基酚磺酰胺配体及在不对称催化中的应用，申请号：202110715362.9，申请公布日：2021年9月28日。
主持课题
1. 重庆市自然科学基金面上项目（cstc2019jcyj-msxmX0034，负责人，已结题）
2. 重庆市教委科技项目青年项目（KJQN201900437，负责人，已结题）
3. 国家自然科学基金面上项目（21672031，负责人，已结题）
4. 重庆市教委科技项目（KJ1500221，负责人，已结题）
5. 药学院青年师资培养项目（YXY2014QNSZ01，负责人，已结题）
6. 重庆市科委基础与前沿研究一般项目 （cstc2013jcyjA10144,负责人，已结题）
7. 国家自然科学基金青年项目（20902114，负责人，已结题）
E-mail：hzhou@cqmu.edu.cn
